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pentobarbital will decrease the level or impact of voriconazole by influencing hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unidentified.Barbiturates can induce hepatic microsomal enzymes resulting in enhanced metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon);